Cisplatin nmr
Antitumor agent cisplatin1 and its derivatives,2,3 when used alone or in combination with other chemotherapeutics4,5 can be effective against the advancement of several clinical cases of cancer. However, there are several known factors such as low selectivity, resistance and consequently, high toxicity that are … See more The calculations were carried out using the GAUSSIAN 09 package.34 The methodology used for the prediction of the NMR chemical shifts … See more In this work we used the relativistic NMR-DKH basis sets for the calculation of the 1H, 15N and 195Pt NMR spectra of inclusion complexes formed between cisplatin and … See more In this work we re-optimize the geometries of the molecular models of cDDP@CNTox or complex I (C168H24O15Cl2N2Pt) and cDDP@CNCox or … See more L. A. De Souza thanks the CAPES for a Post-Doctoral scholarship (Proc. No. 88882.306139/2024-01) during the period 2024–2024 at Universidade Federal Fluminense and support provided by Professor J. C. … See more WebJan 4, 2011 · Abstract. The influences of solvent effects and dynamic averaging on the 195 Pt NMR shielding and chemical shifts of cisplatin and three cisplatin derivatives in …
Cisplatin nmr
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WebJan 11, 2024 · Cisplatin [ cis -diamminedichloridoplatinum (II)] is a widely used chemotherapeutic drug in the treatment of various types of cancers, including testicular, bladder, ovarian, breast, head and neck, and small and non-small cell lung cancers. WebSep 18, 2024 · Cisplatin is a medication used to manage and treat solid tumors and hematologic malignancies. It is in the alkylating agent class of cytotoxic medications. This activity reviews the indications, action, and …
WebNov 13, 2024 · H NMR-based metabolomics strategy was carried out, for the first time to our knowledge, to assess the impact of cisplatin on the metabolism of the kidney , adding the novel study of WebFeb 1, 2012 · Cisplatin, 1, was used as purchased (Sigma-Aldrich, St. Louis, MO). Stock solutions of the platinum compounds in distilled water, 1 and 3, or DPBS (Dulbecco's phosphate buffered saline) buffer, 4, were in the range of 40–650 μM.
WebMay 26, 2024 · Cisplatin is a well-known chemotherapeutic drug for solid tumors and leukemia with muscle toxicity, and long-term cisplatin medication can induce aberrant … WebApr 1, 2014 · 1 H and 13 C NMR spectra were recorded on a Bruker AV 400 NMR spectrometer in DMSO-d 6. Fourier transform infrared (FT-IR) spectra were recorded on a Bio-Rad Win-IR instrument using KBr method. ... Moreover, cisplatin crosslinking could largely enhance micellar stability and might effectively prevent premature drug release …
WebSep 19, 2009 · Cisplatin [ cis -diamminedichloridoplatinum (II)] is used in chemotherapy where platinum–DNA adducts initiate tumor cell death. It is possible that side effects such as neurotoxicity and cellular cisplatin resistance can be due to interaction of cisplatin with lipids and the phospholipid bilayer.
WebSep 25, 2024 · The confirmation of bioconjugation of cisplatin with B-GNPs was done by UV-Visible spectroscopy, TEM, FTIR, 2D 1 H NMR DOSY and ICP-MS. Further, it was found that almost ~4 cisplatin molecules ... ip a in windowsWebSep 18, 2024 · National Center for Biotechnology Information openshift training red hatWebThe purity of the complexes and their stability in solution was confirmed by NMR analysis. The Pt(II) ions in all compounds are in a square planar environment. ... D. Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of Activity, Drug Resistance and Induced Side Effects. Cancers 2011, 3, 1351–1371. [Google Scholar] [Green Version] Cooley ... openshift tutorial udemyWebJun 10, 2024 · NMR-based metabolomics is a very effective tool to assess the tumor response to drugs by providing insights for their mode of action. Recently, a novel Pt (II) complex, [Pt (ƞ 1 -C 2 H 4 OMe) (DMSO) (phen)] + (phen = 1,10-phenanthroline), Pt-EtOMeSOphen, was synthesized and studied for its antitumor activity against eight … ipa investment promotionWebThe paper gives an overview of the basic NMR techniques particularly relevant for studying interaction between platinum compounds and nucleic acid constituents. The latest NMR … openshift tutorial asp.net core 6 sql serverWebOct 22, 2024 · NMR and LCMS analysis highlighted choline, creatine, phosphocholine, valine, acetic acid, phenylalanine, leucine, glutamic acid, threonine, uridine and proline … ipa investmentsWebOct 22, 2024 · In NMR analysis, the effect of C. nutans aqueous extract against cisplatin on NRK-52E was quantitatively determined relative to the concentration of the internal reference standard, trimethylsilyl propionic acid (TSP). The concentration of the metabolites in NRK-52E cells extract and culture media of treated and non-treated groups and their ... openshift workshop