Cisplatin pten

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August undefined, 2024

WebApr 25, 2024 · In this study, we investigate the role of miRs and PTEN in renoprotective effect of curcumin against cisplatin-induced AKI in mice. It is aimed to reveal the mechanism of curcumin which protected the kidney and provided evidence on the therapeutic application of curcumin in alleviating AKI. Go to: Materials and methods Drugs WebPTEN is a tumor-suppressor gene deactivating PI3K downstream of EGFR signaling. We hypothesize that PTEN-deficient lung cancer cells suppressed DNA damage signaling and that the absence of PTEN can sensitize these cells to a concurrent treatment of a DNA-damaging agent (cisplatin) and a PARP inhibitor (olaparib).

Synergistic effect of olaparib with combination of cisplatin on PTEN ...

WebMay 10, 2013 · Cisplatin treatment promotes phosphorylation of AKT. PTEN is known as a negative regulator of AKT phosphorylation. The phosphorylation of AKT was analyzed … WebMay 10, 2013 · PTEN is found to be either inactivated or mutated in various human malignancies. In the present study, we have investigated the regulation of PTEN during cisplatin induced apoptosis in A2780, A270-CP (cisplatin resistant), OVCAR-3 and SKOV3 ovarian cancer cell lines. Methods: Cells were treated with 10μM of cisplatin for 24h. dying is your latest fashion album cover

TP53TG1 enhances cisplatin sensitivity of non-small cell lung …

WebMar 22, 2024 · Diaminodichloroplatinum (cisplatin, DDP) is one of the most effective and widely used DNA-damaging anticancer drugs used for the treatment of various human malignancies including NSCLC [ 4 ]. However, NSCLC patients who are initially sensitive to cisplatin often develop drug resistance, leading to chemotherapy failure [ 5 ]. WebJun 7, 2024 · The PTEN gene was hypothesized to be regulated by miRNA-21 in ovarian cancer cisplatin resistance. Materials and methods Cell lines and cell culture The SKOV3 human ovarian cancer cell line was purchased from Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (Shanghai, China). WebThis is the case of vesicular miR-21 that induced cisplatin resistance in oral squamous cell carcinoma by targeting phosphatase and tensin homolog (PTEN) and programmed cell death protein 4 (PDCD4), which are tumor suppressors involved in apoptosis, cell transformation, invasion, and tumor progression . dying jeans black india ink

Cisplatin (Cisplatin Injection): Uses, Dosage, Side Effects

Role of protein kinase CK2 in antitumor drug resistance

WebCisplatin / pharmacology Cyclin-Dependent Kinase Inhibitor p27 / metabolism Drug Synergism Female Gene Expression Regulation, Neoplastic / drug effects Humans Intracellular Signaling Peptides and Proteins / antagonists & inhibitors Intracellular Signaling Peptides and Proteins / genetics* Intracellular Signaling Peptides and Proteins / … WebMay 10, 2013 · PTEN protein levels were found to be decreased significantly in A2780 cells; however, there was no change in PTEN protein levels in A2780-CP, OVCAR-3 and SKOV3 cells with cisplatin treatment. The decrease in PTEN protein was accompanied with an increase in the levels of AKT phosphorylation (pAKT) in A2780 cells and a decrease of … crystal reports change default printerWebMay 10, 2024 · Although cisplatin (Cis) is an effective chemotherapeutic agent in treatment of various cancers, its adverse effect of nephrotoxicity limits the clinical application. Remote ischemic preconditioning (RIPC) is a strategy to induce resistance in a target organ against the oxidative stress and injury by applying transient, brief episodes of ischemia. dying kitten what to do

"WebSep 24, 2024 · The main lipid substrate of PTEN is PIP 3 and indeed PTEN acts as a negative regulator of PI3K/AKT signaling. ... Wu, D. M. et al. The PAX6-ZEB2 axis promotes metastasis and cisplatin resistance ... " - Cisplatin pten

Cisplatin pten

miR-21 confers cisplatin resistance in gastric cancer cells by ...

WebAug 27, 2024 · Plasmids PTEN-shRNA and PTEN-NC, which contain green fluorescent protein (GFP) and anti-puromycin genes, were extracted from glycerol bacteria and purified according to the manufacturer’s protocols. GC cells were cultured in DMEM/F-12 with 10% FBS in 6-well plates until they reached 70%–80% confluence. WebSpiral ganglion neurons (SGNs) are auditory neurons that relay sound signals from the inner ear to the brainstem. The ototoxic drug cisplatin can damage SGNs and thus lead to sensorineural hearing loss (SNHL), and there are currently no methods for preventing or …

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WebBackground: Platinum-based chemotherapy, cisplatin (DDP) specifically, is the main strategy for treating lung cancer (LC). However, currently, there is a lack of predictive drug-resistance markers, and there is increased interest in the development of a reliable and sensitive panels of markers for DDP chemotherapy-effectiveness prediction. MicroRNAs … WebApr 13, 2024 · HIGHLIGHTS who: Florentine S. B. Subtil et al. from the Department of Radiotherapy and Radiooncology, Philipps-University, Marburg, Germany have published the research: Dual PI3K/mTOR Inhibitor NVP-BEZ235 Leads to a Synergistic … Dual pi3k/mtor inhibitor nvp-bez235 leads to a synergistic enhancement of cisplatin and …

WebSep 15, 2024 · DESCRIPTION. Cisplatin Injection (cisplatin injection (cisplatin (cisplatin injection) injection) ) is a sterile aqueous solution, available in 50, 100 and 200 mL … WebFeb 1, 2013 · We hypothesize that PTEN -deficient lung cancer cells suppressed DNA damage signaling and that the absence of PTEN can sensitize these cells to a concurrent treatment of a DNA-damaging agent (cisplatin) and a PARP inhibitor (olaparib).

WebJul 26, 2013 · In the cytoplasm, PTEN antagonizes the phosphatidylinositol 3-kinase (PI3K) signaling pathway. PTEN also accumulates in the nucleus, where its function remains poorly understood. We demonstrate that SUMOylation (SUMO, small ubiquitin-like modifier) of PTEN controls its nuclear localization.

WebJan 12, 2024 · Cervical cancer is one of the most common female malignancies, and cisplatin-based chemotherapy is routinely utilized in locally advanced cervical cancer patients. However, resistance has been the major limitation. In this study, we found that Na+/H+ Exchanger Regulatory Factor 1 (NHERF1) was downregulated in cisplatin …

WebApr 5, 2013 · In addition, miR-21 induced cell survival and cisplatin resistance through downregulating the expression of phosphatase and tension homolog deleted on chromosome 10 (PTEN) and activation of Akt pathway. Inhibition of Akt using PI3K inhibitor LY 294002 could abrogate miR-21 induced cell survival. dying just the top of your hairWebCisplatin is a chemotherapy drug which is used to treat cancers including: sarcoma, small cell lung cancer, germ cell tumors, lymphoma, and ovarian cancer. While it is often … crystal reports change field sourceWebSep 18, 2024 · NCBI Bookshelf dying kids hair with semi permanent colorWebFeb 7, 2014 · PTEN, a tumor suppressor gene, has been demonstrated to be able to reverse cisplatin-resistance in ovarian cancer cell line C13K. However, the downstream … dying just the front of your hairWebNov 19, 2024 · Cisplatin is an anti-cancer chemotherapy drug which used to treat ovarian cancer in women who have already received surgery and/or radiation treatment. … crystal reports change field being usedWebApr 10, 2024 · Indeed, PTEN serves as a dual-specific phosphatase that suppresses cell proliferation and induces apoptosis and cell cycle arrest via repressing PI3K/Akt signaling mechanisms [208]. Zheng et al. revealed that miR-24 increases the chemoresistance of human TSCC cell lines to cisplatin by downregulating PTEN [209]. crystal reports change filterWebSep 24, 2024 · Cisplatin (CDDP) is the drug of choice against different types of cancer. However, tumor cells can acquire resistance to the damage caused by cisplatin, generating genetic and epigenetic changes that lead to the generation of resistance and the activation of intrinsic resistance mechanisms in cancer cells. Among them, we can find mutations, … dying knowledge enchantment minecraft