Phospholipidosis liver
WebNov 1, 2015 · Its hepatic toxicity is similar to amiodarone, histologically mimicking alcoholic steatohepatitis, associated with phospholipidosis. 111, 112 Pharmacologically, the drug impairs hepatic liver metabolism similarly to amiodarone, concentrating in the mitochondria, uncouples oxidative phosphorylation and inhibits ß-oxidation of fatty acids. WebJun 15, 2008 · Abstract. We have constructed a large-scale transcriptome database of rat liver treated with various drugs. In an effort to identify a biomarker for diagnosis of hepatic phospholipidosis, we extracted 78 probe sets of rat hepatic genes from data of 5 drugs, amiodarone, amitriptyline, clomipramine, imipramine, and ketoconazole, which actually …
Phospholipidosis liver
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WebPhospholipidosis appears to be a generalized systemic effect of cationic amphophilic compounds, such as AD. The cytotoxic pseudoalcoholic changes appear to be an independent phenomenon in susceptible patients, whom we speculate may have been unable or less able to metabolize AD through normal pathways. WebPhospholipidosis and steatosis are two toxic effects, which course with overaccumulation of different classes of lipids in the liver. MS-based lipidomics has become a powerful tool …
WebApr 23, 2024 · Lee et al. created 3D hepatic organoids to predict drug-induced phospholipidosis (PL). They isolated duct cells from human liver tissue and embedded them in Matrigel, followed by the addition of ... WebJan 16, 2015 · It possesses a significant side effect profile that includes hepatotoxicity and cirrhosis. Amiodarone-induced cirrhosis (AIC) is a rare and challenging diagnosis, and …
WebSep 1, 2013 · Ketoconazole was reported to cause phospholipidosis in the liver, lung and spleen (Whitehouse et al., 1994, Pakuts et al., 1990), but little is known about its effects on the kidneys in humans or animals. Thus, our findings about renal phospholipidosis are the first of their kind in ketoconazole-treated mice. WebMar 1, 2016 · National Center for Biotechnology Information
WebOct 1, 2014 · @article{osti_22439848, title = {Dysregulation of protein degradation pathways may mediate the liver injury and phospholipidosis associated with a cationic amphiphilic antibiotic drug}, author = {Mosedale, Merrie and Wu, Hong and Kurtz, C. Lisa and Schmidt, Stephen P. and Adkins, Karissa and Harrill, Alison H. and University of Arkansas for …
WebJul 29, 2024 · It has been suggested that for every 10 cases of alanine aminotransferase (ALT) elevation (>10 times the upper limit of normal) in a clinical trial, there will be one case of more severe liver injury that develops once the drug is widely available [ 30,31 ]. phonak rite hearing aidsWebPhospholipidosis is an excessive intracellular accumulation of phospholipids and drug, which is normally reversible after discontinuation of drug treatment. Currently, it is … how do you handle problems interview questionWebApr 23, 2024 · Drug-induced phospholipidosis (PL) is a storage disorder caused by the formation of phospholipid-drug complexes in lysosomes. Because of the diversity of PL between species, human cell-based assays have been … how do you handle resource overallocationWebMay 12, 2024 · Essential phospholipids can be incorporated as constituents of cell membranes of hepatocytes and thereby improve cellular function through an increase in … how do you handle rejection in sales answerWebScreen for drug-induced liver phospholipidosis and steatosis Cationic amphiphilic drugs are often associated with the induction of phospholipidosis, which is believed to be a precursor event to liver toxicity. how do you handle rejection翻译WebApr 14, 2024 · We emphasize the importance of close monitoring of liver enzymes and evaluation of liver computed tomographic imaging as well as liver biopsy during treatment with amiodarone, and discontinuation should be considered when amiodarone-induced hepatotoxicity is suspected. ... which inhibits removal of lysosomal lipids and leads to … phonak roger covertWebPhospholipidosis is a lysosomal storage disorder characterized by excessive accumulation of intracellular phospholipids in tissues, such as the liver, kidney and lung. It is well … how do you handle negative feedback